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Delaere was one of the earliest and harshest critics of Macchiarinis engineered airways. But as time went on, she could not resist her connection to the dashing surgeon and she violated the number one rule of journalism: Never get involved with a person you're reporting on. All rights reserved. According to the Karolinska Institutes timeline of the Macchiarini case, the institute recruited Macchiarini as a visiting professor of regenerative medicine/stem cell biology in 2010, and the associated Karolinska University Hospital gave him a part-time contract as a consultant and surgeon around the same time. Investigations by the hospital and the Karolinska Institute revealed that issues with Dr. Macchiarinis work had been covered up. Death for Season 2 at Peacock, From 'Truth About Pam' to 'Candy,' True-Crime EPs Tell the Truth (VIDEO). With Macchiarinis exploits endorsed by management and breathlessly reported in the media, it was all too easy to jump on that bandwagon. These included Harriet Wallberg, who was the vice-chancellor of the Karolinska Institute in 2010, when Macchiarini was recruited. Next month, she will turn 57. Family Seeks JusticeAfter Her Disappearance, Oregon Mother Of Four Who Was To Meet Up With Teen Son Suddenly Vanishes, Husband Of Missing Massachusetts Woman Charged With Her Murder, 8 Things To Know About The Nicholas Barclay Disappearance And Ensuing Deception, I'm Still Searching For My Baby: Georgia Mother Hopes For Answers In Daughters Disappearance, A Woman Disappeared From A Group Hike And Was Never Seen Again. He is from Italy. Why dont the Electoral College and popular vote always match up? It won Dr. Macchiarini international news coverage and cemented his place as a celebrity scientist. The 18-hour procedure, conceived and led by Dr. Eric M. Genden Sr., chairman of otolaryngology-head and neck surgery at Mount Sinai Health System in New York, is a milestone because unlike kidneys, hearts and lungs the trachea has defied decades of transplantation attempts. 2023 Warner Bros. By the time the program aired, in mid-2014, the couple were planning their marriage. Disgraced Italian surgeon convicted of criminal harm to stem cell patient. How climate change and forest management make wildfires harder to contain, Disparity in police response: Black Lives Matter protests and Capitol riot. Please try again later. Ground-breaking work on synthetic organ transplants made Paolo Macchiarini one of the most famous doctors in the world. The coronavirus pandemic will most likely create more cases because many Covid-19 patients have needed weeks on ventilators. Vanity Fair also later discovered that several of Paolo's other statements were false, including his claims about having been an associate professor at the University of Pisa. But the vice-chancellor of Karolinska Institute, Anders Hamsten, wasnt bound by this judgement. Andemariam Beyene met up with Macchiarini in Iceland a year after his operation but later died Two more patients were also given transplants at the Karolinska Colorado Prosecutors dropped the case a few months later, however, saying they didnt have sufficient evidence to prove manslaughter. A life-saver and a game-changer. Its kind of a marginal substitute, and many patients need further interventions to maintain their airways.. About 11 centimeters (4 inches) long, one side curves like a halfpipe, composed of cartilage rings and ligaments. Paolo was in the house, but he was not alone after Benita's friends were asked to leave, they noticed a blonde woman coming out of the house, with two young children. A genius is a revolutionary by definition, a risk-taker and a law-breaker. Paolo Macchiarini is exposed Reality struck Alexander's fantasy romance eight weeks before she was supposed to marry Macchiarini in 2015, when she received an email from a colleague with the subject line saying, "The Pope." So, as per the last reports, he is alive and well today. The story portrayed Macchiarini, who was already married at the time, as a serial fabulist who exaggerated or lied about degrees, academic appointments, and personal accomplishments. A 29-year old woman from New Brunswick, New Jersey, posed as a high school student and attended classes for four days before she was caught and arrested. She received a new trachea in January and is believed to be the first patient in the world to undergo a successful direct transplant of a donor trachea. The university board was dismissed and even Harriet Wallberg, whod moved on to become the chancellor for all Swedish universities, lost her job. Karolinskas leadership expected big things from their superstar, things that would bring prestige and funding to the institute. 2023 American Association for the Advancement of Science. And the TV shows second season, announced earlier this month, will cover the podcasts third, with Edgar Ramirez playing Paolo Macchiarini, and This Is Us star Mandy Moore playing Benita Alexander, an investigative journalist who falls into a whirlwind romance with the doctor. There Was Nothing Anybody Could Do for These Patients. Now There Is. And after hiring a private investigator, Ms Alexander found that Dr Macchiarini, pictured, was a man of more modest means living in Barcelona and that he was still married to his wife of 30 years Ms Alexander told Vanity Fair: 'I just didn't want to put two and two together. If the sins of Karolinska have been committed elsewhere, it is partly because medical research facilities share a common milieu, which harbours common dangers. Selena died in a hospital due to a loss of blood and cardiac arrest, two weeks before her 24th birthday. https://www.nytimes.com/2021/04/06/health/trachea-transplant-genden.html. Some answers have emerged from the official inquiries into the Karolinska Institute and the Karolinska University hospital. Macchiarini is known for his research fraud and manipulative behavior. Most, including Andemariam Beyene, are now dead. The answer came only a couple of weeks later, when Swedish television began broadcasting a three-part expos of Macchiarini and his work. And Murphy found that Macchiarinis claims about the wedding were almost all untrue and that the surgeon was married and had been for nearly 30 years. "Maybe it happened because I am a journalist, and once I sort of woke up and put my journalist hat back on, I could expose him," she said. Here are 13 more things about him: Categories: biographical data, crimes, Europe, fitness & health, Italy, Lifestyle, LISTS, Russia, Social Issues, Sweden, Tagged as: Basel, Benita Alexander, Emanuela Pecchia, Paolo Macchiarini. They didnt. When Macchiarini accused one of them, Karl-Henrik Grinnemo, of stealing his work in a grant application, Hamsten found him guilty. The Karolinska Institute declined to comment for this article, noting only that Dr. Macchiarinis sentence may be appealed. Stem-cell scientist Dr. Paolo Macchiarini was accused of wrongdoing during operations on three people between 2011 and 2014. According to the Times, Macchiarini seen below in a 2017 interview on Swedens TV4 Nyheterna performed 20 tracheal regeneration procedures across Europe and in the United States but hid the fact that the transplants were failing. Thousands of people in the United States alone develop trachea problems each year from burns, birth defects, tumors and extended intubation on ventilators. The procedure involved replacing a damaged trachea with a plastic replica that had been soaked in the patients stem cells. Wasnt something of this idea behind the special treatment Karolinska gave Macchiarini? In January 2016, Macchiarini received an extraordinary double dose of bad press. On Friday Mr. Hurtig declined to comment on Paolos private affairs.. In other countries, more of Macchiarinis patients died after receiving one of his artificial windpipes. As he said in Experimenten: If I had the option of a synthetic trachea or a firing squad, Id choose the last option because it would be the least painful form of execution.. "I have to tell people. But according to reports, Paolo cheated on his Emanuela Pecchia. Paolo Macchiarini, in a 2013 photo, implanted synthetic windpipes into multiple patients; all but one died following complications with the implants. Photographs document Ms. Seins trachea transformation: Her old windpipe looks raw and red, her new one smooth as porcelain. Previously considered a pioneer for using both biological and synthetic scaffolds As it turned out, Macchiarinis patients werent all at deaths door at the time he treated them. Her friends described him as "Mr. Big" from Sex and the City. So I called and called till I got an appointment., Dr. Genden said Ms. Sein beseeched him for the transplant, saying, You need to do this for me or Im going to end my life.. (The big exception is blood stem cell transplantation, which has been saving the lives of people with leukemia and other cancers of the blood for decades.). Swedish television broadcast a three-part expos of Paolo's work called Experimenten, which argued that the artificial windpipes did more harm than good and were actually rotting away inside his patients' bodies. Watch He Lied About Everything on ID GO now! Dr. Paolo Macchiarini at the Karolinska Institute in Stockholm in 2013. Only four months after Macchiarini operated on Claudia Castillo, his results provisional but very positive were published online by the Lancet. He says prosecutors should have pressed for manslaughter charges because Macchiarini had no evidence that the tracheas he implanted would develop into normally functioning organs. She received a new trachea in January and is believed to be the first patient in the world to undergo a successful direct transplant of a donor trachea.CreditSarah Blesener for The New York Times. They exchange their vows in Italy. They exchange their vows in Italy. One of these is the hype surrounding stem cells. For six years, she had endured a tube inserted in her windpipe, or trachea, to keep her alive, but her discomfort and distress were becoming more and more unbearable. Benita Alexander and Paolo Macchiarini in Venice, Italy [Investigation Discovery]. Dr. Gerdin said Dr. Macchiarini was allowed to continue his procedures for so long because the Karolinska Institute and its hospital allowed him to do so. Michigan Four of Macchiarinis colleagues at KI, including Corbascio, filed official complaints in 2014 charging that several papers describing the surgeries deliberately left out serious complications in the patients. None other than Pope Francis would officiate, and his papal palace in Castel Gandolfo would serve as the venue. Nor did they impress the institutes ethics council when Delaere lodged a formal complaint. The couple had traveled a lot, but there were some things Source: ABC Article continues below advertisement His relationship with Benita, Keep up with your favorite shows delivered to your inbox! Her transformation follows a groundbreaking experimental procedure she underwent in January: the first time, medical experts believe, a donor trachea has been successfully directly transplanted into another person. An alarmingly wide gap has grown between what we expect from stem cells and what they deliver. Likewise the secretary-general of the Nobel Committee. Macchiarini, who denied the charges against him, wasnt directly accused of killing any of the three patients. Few people at Karolinska, especially among those in power, knew enough about it to appreciate Delaeres claims. Benita first met Paolo at the bar at Bostons Mandarin Oriental hotel in February 2013, when she was helping coordinate an interview for an NBC special on regenerative medicine. Benita packed her bags again, and began to search for Paolo in order to face him once more and their final confrontation is captured in He Lied About Everything. On the contrary, they seemed to do more harm than good something that Macchiarini had for years concealed or downplayed in his scientific articles, press releases and interviews. Death Season 2, Mandy Moore Joins Dr. A Swedish filmmakers investigative documentary raised further questions, as did a Vanity Fair article detailing how the beguiling surgeon became romantically involved with an NBC producer working on a feature about him and apparently conned her into believing he was divorced and would marry her in a ceremony officiated by the pope and attended by the Clintons, Obamas, John Legend and Elton John. He convinced the Karolinska Institute that this could make them famous, and they just let him do it. She had subsequently undergone six major surgeries and more than 10 smaller procedures, but with all conventional approaches to address her condition exhausted, she made plans to have the tube removed and receive only palliative care. But it did not work, and a court in Sweden has found him criminally liable for the harm In Macchiarinis case, the hope was that patients could be treated with stem cells taken from their own bone marrow. North Carolina In addition to his partner of over 30 years, he also had a special next woman. In court testimony, he defended himself as only trying to help desperately ill patients, and said he had the full support of KI and his colleagues. In late 2014, four doctors in Sweden accused him of fraud, saying that he'd falsified data in six of the papers he had published. At night, when she connected her tracheal tube to a ventilator, the alarm kept going off to let people know that I stopped breathing, said Ms. Sein, who hated causing her family concern. Its very exciting, said Dr. G. Alexander Patterson, a professor of surgery at Washington University in St. Louis, who was not involved in the case. Earliest evidence of horseback riding found in eastern cowboys, Funding woes force 500 Women Scientists to scale back operations, Lawmakers offer contrasting views on how to compete with China in science, U.K. scientists hope to regain access to EU grants after Northern Ireland deal, Astronomers stumble in diplomatic push to protect the night sky, Satellites spoiling more and more Hubble images, Pablo Neruda was poisoned to death, a new forensic report suggests, Europes well-preserved bog bodies surrender their secrets, Teens leukemia goes into remission after experimental gene-editing therapy, Disgraced stem cell surgeon convicted of criminal harm, Disgraced surgeon is still publishing on stem cell therapies, Six papers by disgraced surgeon should be retracted, report concludes, Former star surgeon's disgrace rocks Swedish science. I have to expose him.". (LogOut/ They should be. Its a problematic idea with unfortunate side effects. The first successful direct transplant of a trachea is a medical milestone that could help thousands of people with airways damaged by ventilators and other causes. As a subscriber, you have 10 gift articles to give each month. Anyone can read what you share. Plus: NYC sixth-grader struck and killed by stray bullet; New Hampshire police search for person of interest in double homicide; Fyre Festival fraudster released early from prison; and manhunt continues for escaped Texas prisoner. But of 20 patients, including children, most ultimately died, and scientists said Dr. Macchiarini misrepresented data and exaggerated his techniques effectiveness. Award-winning documentary-maker Benita Alexander was swept off her feet by renowned Italian doctor Paolo Macchiarini in 2013 while she was working on a story about his pioneering medical work. Faced with this public relations disaster, the Karolinska Institute immediately promised to investigate the allegations but then, within days, suddenly announced that Macchiarinis contract would not be extended. We would have been planning my funeral, she said, but now were planning a birthday party.. A version of this story appeared in Science, Vol 376, Issue 6600. At the time, Macchiarini was working at Swedens Karolinska Institute, which awards the Nobel Prize in Physiology or Medicine every year. Paolo stated in an interview with a TV station in Iceland that he has always acted in the patients' best interest, and believes that his procedures should be seen as successful. Other trachea replacement attempts include transplanting part of a donors frozen, preserved aorta, the bodys main artery, and fabricating tracheas from patients own chest muscles and rib cartilage. Was he conning his patients, his colleagues and the scientific community? Thailand The court had to apply the intentional indifference standard for the assault charges, he says, which is difficult to prove. Claudia Castillo with Dr Paolo Macchiarini. Dont yet have access? Now they were on the wedding guest list: the Obamas, the Clintons, Vladimir Putin, Nicolas Sarkozy and other world leaders. It relieved a little bit of burden from him.. This guy mutilated people., Between 2011 and 2014, Macchiarini implanted artificial windpipes in at least eight patients in Sweden, the United States, and Russia. Please make a tax-deductible gift today. Chinese balloon photos Benita Alexander on attending Paolo Macchiarinis criminal trial in Sweden Alexander said she attended Macchiarini's trial for closure, seven years after she was unknowingly caught in a fraudulent romance with him, and for justice for his patients and for their families. July 21, 2022 Examined 9:54 Whats next for Russia? All rights reserved. Most protagonists on medical dramas are modern-day heroes. The Karolinska University Hospital suspended Dr. Macchiarinis contract as a surgeon in 2013, but the affiliated Karolinska Institute kept him on until 2016 even as the scandal over his work spread, according to a timeline on the institutes website. Macchiarini told people that Barack and Michelle Obama, Bill and Hillary Clinton, Nicolas Sarkozy, and Vladimir Putin would attend the wedding, Andrea Bocelli would perform, and Pope Francis (a patient of his, or so he said) would officiate the ceremony, per Vanity Fair. Heres this handsome Italian surgeon at the finest institution in the world, the Karolinska, and hes everything Im not: Hes got a beautiful head of hair, he drives a motorcycle, hes got an accent, hes incredibly charismatic and dynamic, Dr. Genden said. Dr. Paolo Macchiarini became a star by creating a bioartificial windpipe. Andrea Bocelli was to sing at the ceremony. Allegations also emerged that the risky procedure was performed on at least one person who was not critically ill at the time. Over the years, this possibility has generated great excitement and a huge amount of research. As the home of the Nobel prize in physiology or medicine, one of its ambitions is to create scientific celebrities. She soon went into full-on investigative journalist mode, and learned that Paolo had, yup lied about everything. She had already spent $10,000 on engraved invitations made for a guest list that included the Obamas, the Clintons, Vladimir Putin, and Elton John. It is thus likely she has since passed away. Thats what our experience of medical research leads us to suspect. I could feel it in my lungs.. Ms. Seins trachea before, left, and her new transplanted trachea. I Googled trachea transplant and Dr. Genden popped up. Starting in 2011, Macchiarini performed three transplantations of synthetic tracheas at Karolinska University Hospital, but one of those patients died in 2012, the timeline reports. At the time, Macchiarini was employed by the prestigious Karolinska Institute in Sweden. He traveled to Illinois to operate on a Korean toddler who was born without a trachea and who was going to be the youngest person to ever receive an artificial one. After Macchiarini fitted Cetir with one of his artificial windpipes in 2012, her condition worsened. The first was a Vanity Fair article about his affair with Benita Alexander, an award-winning producer for NBC News. In June 2016, the public prosecutor's office began investigating Paolo on suspicion of manslaughter and grievous bodily harm based on the material leading to the deaths of the three patients operated on in Sweden. The other side is flat and mobile to move air to the lungs. Paolo grew close to Alexander's daughter [Investigation Discovery], He was incredibly charming, worldly smart, sophisticated, and seemed very gentle," Benita told CrimeFeed. However, the serious complications that Castillo suffered were, for a long time, kept very quiet. Now his reputation lies in tatters. Called Experimenten (The Experiments), it argued convincingly that Macchiarinis artificial windpipes were not the life-saving wonders wed all been led to believe. He has been convicted of research-related crimes in Italy and Sweden. Benita said that, if she can take any lessons away from what happened to her, she hopes that her experience will help others. But it was already too late. The felony conviction means Macchiarini would have a hard time finding employment again in Sweden, Gerdin says. They planned to marry in the Catholic Church in Italy. An unhappy result of this is the rise of pseudo-scientific therapies. US Capitol Likewise the whole idea of a wedding: Macchiarini was still married to his wife of 30 years. Almost immediately after she was fitted with a synthetic trachea in August 2012, Ms. Cetirs condition began to rapidly deteriorate, according to the courts written judgment. According to a witness report, Paolo operated on a 45-50-year-old woman of Middle Eastern origin in a private clinic in Barcelona in the fall of 2008. Brazilian MMA fighters Macchiarini shot to prominence back in 2008, when he created a new airway for Claudia Castillo, a young woman from Barcelona. Chatri Sityodtong At the trial, Macchiarini and his lawyer argued that the patients, with no other options, had been treated under compassionate care standards. Benita Alexander and Paolo Macchiarini [Investigation Discovery]. 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paolo macchiarini wife of 30 years